Increased separase activity and occurrence of centrosome aberrations concur with transformation of MDS

ESPL1/separase, a cysteine endopeptidase, is a key player in centrosome duplication and mitotic sister chromatid separation. Aberrant expression and/or altered separase proteolytic activity are associated with centrosome amplification, aneuploidy, tumorigenesis and disease progression. Since centros...

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Detalles Bibliográficos
Autores principales: Ruppenthal, Sabrina, Kleiner, Helga, Nolte, Florian, Fabarius, Alice, Hofmann, Wolf-Karsten, Nowak, Daniel, Seifarth, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784974/
https://www.ncbi.nlm.nih.gov/pubmed/29370237
http://dx.doi.org/10.1371/journal.pone.0191734

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784974/
https://www.ncbi.nlm.nih.gov/pubmed/29370237
http://dx.doi.org/10.1371/journal.pone.0191734

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