SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia

Insulin secretion is initiated by activation of voltage-gated Ca(2+) channels (VGCC) to trigger Ca(2+)-mediated insulin vesicle fusion with the β-cell plasma membrane. The firing of VGCC requires β-cell membrane depolarization, which is regulated by a balance of depolarizing and hyperpolarizing ioni...

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Detalles Bibliográficos
Autores principales: Kang, Chen, Xie, Litao, Gunasekar, Susheel K., Mishra, Anil, Zhang, Yanhui, Pai, Saachi, Gao, Yiwen, Kumar, Ashutosh, Norris, Andrew W., Stephens, Samuel B., Sah, Rajan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785485/
https://www.ncbi.nlm.nih.gov/pubmed/29371604
http://dx.doi.org/10.1038/s41467-017-02664-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785485/
https://www.ncbi.nlm.nih.gov/pubmed/29371604
http://dx.doi.org/10.1038/s41467-017-02664-0

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