Development of novel fluorescent histamine H(1)-receptor antagonists to study ligand-binding kinetics in living cells

The histamine H(1)-receptor (H(1)R) is an important mediator of allergy and inflammation. H(1)R antagonists have particular clinical utility in allergic rhinitis and urticaria. Here we have developed six novel fluorescent probes for this receptor that are very effective for high resolution confocal...

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Detalles Bibliográficos
Autores principales: Stoddart, Leigh A., Vernall, Andrea J., Bouzo-Lorenzo, Monica, Bosma, Reggie, Kooistra, Albert J., de Graaf, Chris, Vischer, Henry F., Leurs, Rob, Briddon, Stephen J., Kellam, Barrie, Hill, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785503/
https://www.ncbi.nlm.nih.gov/pubmed/29371669
http://dx.doi.org/10.1038/s41598-018-19714-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785503/
https://www.ncbi.nlm.nih.gov/pubmed/29371669
http://dx.doi.org/10.1038/s41598-018-19714-2

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