Necessity of p53-binding to the CDH1 locus for its expression defines two epithelial cell types differing in their integrity

TP53 mutation (i.e., loss of normal-p53) may evoke epithelial-mesenchymal transition (EMT), which was previously attributed to loss of certain miRNAs. However, not all epithelial cells undergo EMT upon TP53 mutation, and the p53-miRNA axis may not fully explain p53 function in epithelial integrity....

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Detalles Bibliográficos
Autores principales: Oikawa, Tsukasa, Otsuka, Yutaro, Onodera, Yasuhito, Horikawa, Mei, Handa, Haruka, Hashimoto, Shigeru, Suzuki, Yutaka, Sabe, Hisataka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785525/
https://www.ncbi.nlm.nih.gov/pubmed/29371630
http://dx.doi.org/10.1038/s41598-018-20043-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785525/
https://www.ncbi.nlm.nih.gov/pubmed/29371630
http://dx.doi.org/10.1038/s41598-018-20043-7

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