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Pharmacokinetic parameters explain the therapeutic activity of antimicrobial agents in a silkworm infection model
Poor pharmacokinetic parameters are a major reason for the lack of therapeutic activity of some drug candidates. Determining the pharmacokinetic parameters of drug candidates at an early stage of development requires an inexpensive animal model with few associated ethical issues. In this study, we u...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785531/ https://www.ncbi.nlm.nih.gov/pubmed/29371643 http://dx.doi.org/10.1038/s41598-018-19867-0 |