Cargando…

Pharmacokinetic parameters explain the therapeutic activity of antimicrobial agents in a silkworm infection model

Poor pharmacokinetic parameters are a major reason for the lack of therapeutic activity of some drug candidates. Determining the pharmacokinetic parameters of drug candidates at an early stage of development requires an inexpensive animal model with few associated ethical issues. In this study, we u...

Descripción completa

Detalles Bibliográficos
Autores principales:	Paudel, Atmika, Panthee, Suresh, Urai, Makoto, Hamamoto, Hiroshi, Ohwada, Tomohiko, Sekimizu, Kazuhisa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785531/ https://www.ncbi.nlm.nih.gov/pubmed/29371643 http://dx.doi.org/10.1038/s41598-018-19867-0

Ejemplares similares

Advantages of the Silkworm As an Animal Model for Developing Novel Antimicrobial Agents
por: Panthee, Suresh, et al.
Publicado: (2017)

Novel Pathogenic Mucorales Identified Using the Silkworm Infection Model
por: Panthee, Suresh, et al.
Publicado: (2021)

A Novel Spiro-Heterocyclic Compound Identified by the Silkworm Infection Model Inhibits Transcription in Staphylococcus aureus
por: Paudel, Atmika, et al.
Publicado: (2017)

Draft Genome Sequence of the Vancomycin-Resistant Clinical Isolate Staphylococcus aureus VRS3b
por: Panthee, Suresh, et al.
Publicado: (2017)

GPI0363 inhibits the interaction of RNA polymerase with DNA in Staphylococcus aureus
por: Paudel, Atmika, et al.
Publicado: (2019)

Complete Genome Sequence of Weissella hellenica 0916-4-2 and Its Comparative Genomic Analysis
por: Panthee, Suresh, et al.
Publicado: (2019)

YjbH regulates virulence genes expression and oxidative stress resistance in Staphylococcus aureus
por: Paudel, Atmika, et al.
Publicado: (2021)

Utilization of Hybrid Assembly Approach to Determine the Genome of an Opportunistic Pathogenic Fungus, Candida albicans TIMM 1768
por: Panthee, Suresh, et al.
Publicado: (2018)

The Role of Amino Acid Substitution in HepT Toward Menaquinone Isoprenoid Chain Length Definition and Lysocin E Sensitivity in Staphylococcus aureus
por: Panthee, Suresh, et al.
Publicado: (2020)

Hybrid assembly using long reads resolves repeats and completes the genome sequence of a laboratory strain of Staphylococcus aureus subsp. aureus RN4220
por: Panthee, Suresh, et al.
Publicado: (2022)

Pharmacokinetics of anti-infectious reagents in silkworms
por: Hamamoto, Hiroshi, et al.
Publicado: (2019)

Discovery of gramicidin A analogues with altered activities by multidimensional screening of a one-bead-one-compound library
por: Takada, Yuri, et al.
Publicado: (2020)

Transcriptome change of Staphylococcus aureus in infected mouse liver
por: Hamamoto, Hiroshi, et al.
Publicado: (2022)

Development of a high-throughput strategy for discovery of potent analogues of antibiotic lysocin E
por: Itoh, Hiroaki, et al.
Publicado: (2019)

Use of silkworms for identification of drug candidates having appropriate pharmacokinetics from plant sources
por: Asami, Yukihiro, et al.
Publicado: (2010)

Serum apolipoprotein A-I potentiates the therapeutic efficacy of lysocin E against Staphylococcus aureus
por: Hamamoto, Hiroshi, et al.
Publicado: (2021)

In vitro antibacterial activity and in vivo therapeutic effect of Sesbania grandiflora in bacterial infected silkworms
por: Anantaworasakul, Pimporn, et al.
Publicado: (2017)

Silkworm model for Bacillus anthracis infection and virulence determination
por: Paudel, Atmika, et al.
Publicado: (2021)

Silkworm as an experimental animal for research on fungal infections
por: Matsumoto, Yasuhiko, et al.
Publicado: (2019)

Staphylococcus aureus aggregation in the plasma fraction of silkworm hemolymph
por: Ryuno, Hiroki, et al.
Publicado: (2019)

Comparative analysis of COVID‐19 case fatality rate between two waves in Nepal
por: GC, Sulochan, et al.
Publicado: (2021)

Diabetic silkworms for evaluation of therapeutically effective drugs against type II diabetes
por: Matsumoto, Yasuhiko, et al.
Publicado: (2015)

Enterococcus faecalis YM0831 suppresses sucrose-induced hyperglycemia in a silkworm model and in humans
por: Matsumoto, Yasuhiko, et al.
Publicado: (2019)

Primed Immune Responses Triggered by Ingested Bacteria Lead to Systemic Infection Tolerance in Silkworms
por: Miyashita, Atsushi, et al.
Publicado: (2015)

Establishment of a Bacterial Infection Model Using the European Honeybee, Apis mellifera L
por: Ishii, Kenichi, et al.
Publicado: (2014)

Evaluation of drug-induced tissue injury by measuring alanine aminotransferase (ALT) activity in silkworm hemolymph
por: Inagaki, Yoshinori, et al.
Publicado: (2012)

A novel application of bubble-eye strain of Carassius auratus for ex vivo fish immunological studies
por: Nakajima, Hiroto, et al.
Publicado: (2021)

Fluorescence imaging for a noninvasive in vivo toxicity-test using a transgenic silkworm expressing green fluorescent protein
por: Inagaki, Yoshinori, et al.
Publicado: (2015)

Establishment of a polymerase chain reaction-based method for strain-level management of Enterococcus faecalis EF-2001 using species-specific sequences identified by whole genome sequences
por: Hamamoto, Hiroshi, et al.
Publicado: (2022)

Lactobacillus paraplantarum 11-1 Isolated from Rice Bran Pickles Activated Innate Immunity and Improved Survival in a Silkworm Bacterial Infection Model
por: Nishida, Satoshi, et al.
Publicado: (2017)

Diversity of Antimicrobial Peptides in Silkworm
por: Makwana, Pooja, et al.
Publicado: (2023)

Fear, Risk Perception, and Engagement in Preventive Behaviors for COVID-19 during Nationwide Lockdown in Nepal
por: Khanal, Ashok, et al.
Publicado: (2022)

Pharmacokinetics of metoclopramide in calves with renal dysfunction
por: TAKAYASU, Mariko, et al.
Publicado: (2014)

Evaluation of Anti-Mycobacterial Compounds in a Silkworm Infection Model with Mycobacteroides abscessus
por: Hosoda, Kanji, et al.
Publicado: (2020)

Clinical and epidemiological features of COVID-19 deaths in Nepal
por: Panthee, B., et al.
Publicado: (2020)

COVID-19: the current situation in Nepal
por: Panthee, B., et al.
Publicado: (2020)

An invertebrate infection model for evaluating anti-fungal agents against dermatophytosis
por: Ishii, Masaki, et al.
Publicado: (2017)

Pharmacokinetics/Pharmacodynamics models of veterinary antimicrobial agents
por: Luo, Wanhe, et al.
Publicado: (2019)

Specific Expression of Antimicrobial Peptides from the Black Soldier Fly in the Midgut of Silkworms (Bombyx mori) Regulates Silkworm Immunity
por: Deng, Xuan, et al.
Publicado: (2023)

β-carboline chemical signals induce reveromycin production through a LuxR family regulator in Streptomyces sp. SN-593
por: Panthee, Suresh, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_1pljf80hfafo3ts4kbb29ikv1v