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Pharmacokinetic parameters explain the therapeutic activity of antimicrobial agents in a silkworm infection model

Poor pharmacokinetic parameters are a major reason for the lack of therapeutic activity of some drug candidates. Determining the pharmacokinetic parameters of drug candidates at an early stage of development requires an inexpensive animal model with few associated ethical issues. In this study, we u...

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Detalles Bibliográficos
Autores principales:	Paudel, Atmika, Panthee, Suresh, Urai, Makoto, Hamamoto, Hiroshi, Ohwada, Tomohiko, Sekimizu, Kazuhisa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785531/ https://www.ncbi.nlm.nih.gov/pubmed/29371643 http://dx.doi.org/10.1038/s41598-018-19867-0

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