Structural Dynamics of the GW182 Silencing Domain Including its RNA Recognition motif (RRM) Revealed by Hydrogen-Deuterium Exchange Mass Spectrometry

The human GW182 protein plays an essential role in micro(mi)RNA-dependent gene silencing. miRNA silencing is mediated, in part, by a GW182 C-terminal region called the silencing domain, which interacts with the poly(A) binding protein and the CCR4-NOT deadenylase complex to repress protein synthesis...

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Detalles Bibliográficos
Autores principales: Cieplak-Rotowska, Maja K., Tarnowski, Krzysztof, Rubin, Marcin, Fabian, Marc R., Sonenberg, Nahum, Dadlez, Michal, Niedzwiecka, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785596/
https://www.ncbi.nlm.nih.gov/pubmed/29080206
http://dx.doi.org/10.1007/s13361-017-1830-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785596/
https://www.ncbi.nlm.nih.gov/pubmed/29080206
http://dx.doi.org/10.1007/s13361-017-1830-9

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