Inhibition of Farnesyltransferase Potentiates NOTCH-Targeted Therapy against Glioblastoma Stem Cells

Accumulating evidence suggests that cancer cells with stem cell-like phenotypes drive disease progression and therapeutic resistance in glioblastoma (GBM). NOTCH regulates self-renewal and resistance to chemoradiotherapy in GBM stem cells. However, NOTCH-targeted γ-secretase inhibitors (GSIs) exhibi...

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Detalles Bibliográficos
Autores principales: Ma, Yufang, Cheng, Zhixiang, Liu, Jing, Torre-Healy, Luke, Lathia, Justin D., Nakano, Ichiro, Guo, Yan, Thompson, Reid C., Freeman, Michael L., Wang, Jialiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785731/
https://www.ncbi.nlm.nih.gov/pubmed/29198824
http://dx.doi.org/10.1016/j.stemcr.2017.10.028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785731/
https://www.ncbi.nlm.nih.gov/pubmed/29198824
http://dx.doi.org/10.1016/j.stemcr.2017.10.028

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