How powerful are summary-based methods for identifying expression-trait associations under different genetic architectures?

Transcriptome-wide association studies (TWAS) have recently been employed as an approach that can draw upon the advantages of genome-wide association studies (GWAS) and gene expression studies to identify genes associated with complex traits. Unlike standard GWAS, summary level data suffices for TWA...

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Detalles Bibliográficos
Autores principales: Veturi, Yogasudha, Ritchie, Marylyn D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785784/
https://www.ncbi.nlm.nih.gov/pubmed/29218884

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785784/
https://www.ncbi.nlm.nih.gov/pubmed/29218884

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