Screening a small molecule library to identify inhibitors of NF-κB inducing kinase and pro-labor genes in human placenta

The non-canonical NF-κB signaling (RelB/p52) pathway drives pro-labor genes in the human placenta, including corticotropin-releasing hormone (CRH) and cyclooxygenase-2 (COX-2), making this a potential therapeutic target to delay onset of labor. Here we sought to identify small molecule compounds fro...

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Detalles Bibliográficos
Autores principales: Wang, Bingbing, Parobchak, Nataliya, Martin, Adriana, Rosen, Max, Yu, Lumeng Jenny, Nguyen, Mary, Gololobova, Kseniya, Rosen, Todd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785954/
https://www.ncbi.nlm.nih.gov/pubmed/29374256
http://dx.doi.org/10.1038/s41598-018-20147-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785954/
https://www.ncbi.nlm.nih.gov/pubmed/29374256
http://dx.doi.org/10.1038/s41598-018-20147-0

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