New role of phenothiazine derivatives as peripherally acting CB1 receptor antagonizing anti-obesity agents

Developing peripherally active cannabinoid 1 (CB1) receptor antagonists is a novel therapeutic approach for the management of obesity. An unusual phenothiazine scaffold containing CB1R antagonizing hit was identified by adopting virtual screening work flow. The hit so identified was further modified...

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Detalles Bibliográficos
Autores principales: Sharma, Mayank Kumar, Machhi, Jatin, Murumkar, Prashant, Yadav, Mange Ram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785958/
https://www.ncbi.nlm.nih.gov/pubmed/29374224
http://dx.doi.org/10.1038/s41598-018-20078-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785958/
https://www.ncbi.nlm.nih.gov/pubmed/29374224
http://dx.doi.org/10.1038/s41598-018-20078-w

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