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New role of phenothiazine derivatives as peripherally acting CB1 receptor antagonizing anti-obesity agents
Developing peripherally active cannabinoid 1 (CB1) receptor antagonists is a novel therapeutic approach for the management of obesity. An unusual phenothiazine scaffold containing CB1R antagonizing hit was identified by adopting virtual screening work flow. The hit so identified was further modified...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785958/ https://www.ncbi.nlm.nih.gov/pubmed/29374224 http://dx.doi.org/10.1038/s41598-018-20078-w |