A dynamic allosteric pathway underlies Rad50 ABC ATPase function in DNA repair

The Mre11-Rad50 protein complex is an initial responder to sites of DNA double strand breaks. Many studies have shown that ATP binding to Rad50 causes global changes to the Mre11-Rad50 structure, which are important for DNA repair functions. Here we used methyl-based NMR spectroscopy on a series of...

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Detalles Bibliográficos
Autores principales: Boswell, Zachary K., Rahman, Samiur, Canny, Marella D., Latham, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786021/
https://www.ncbi.nlm.nih.gov/pubmed/29374232
http://dx.doi.org/10.1038/s41598-018-19908-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786021/
https://www.ncbi.nlm.nih.gov/pubmed/29374232
http://dx.doi.org/10.1038/s41598-018-19908-8

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