The E(2.65)A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors

The dopamine D2 and D3 receptors (D2R and D3R) are important targets for antipsychotics and for the treatment of drug abuse. SB269652, a bitopic ligand that simultaneously binds both the orthosteric binding site (OBS) and a secondary binding pocket (SBP) in both D2R and D3R, was found to be a negati...

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Detalles Bibliográficos
Autores principales: Verma, Ravi Kumar, Abramyan, Ara M., Michino, Mayako, Free, R. Benjamin, Sibley, David R., Javitch, Jonathan A., Lane, J. Robert, Shi, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786319/
https://www.ncbi.nlm.nih.gov/pubmed/29337986
http://dx.doi.org/10.1371/journal.pcbi.1005948

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786319/
https://www.ncbi.nlm.nih.gov/pubmed/29337986
http://dx.doi.org/10.1371/journal.pcbi.1005948

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