Two Distinct Pathways in Mice Generate Antinuclear Antigen-Reactive B Cell Repertoires

The escape of anti-self B cells from tolerance mechanisms like clonal deletion, receptor editing, and anergy results in the production of autoantibodies, which is a hallmark of many autoimmune disorders. In this study, we demonstrate that both germline sequences and somatic mutations contribute to a...

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Detalles Bibliográficos
Autores principales: Faderl, Martin, Klein, Fabian, Wirz, Oliver F., Heiler, Stefan, Albertí-Servera, Llucia, Engdahl, Corinne, Andersson, Jan, Rolink, Antonius
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786517/
https://www.ncbi.nlm.nih.gov/pubmed/29403498
http://dx.doi.org/10.3389/fimmu.2018.00016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786517/
https://www.ncbi.nlm.nih.gov/pubmed/29403498
http://dx.doi.org/10.3389/fimmu.2018.00016

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