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Two Distinct Pathways in Mice Generate Antinuclear Antigen-Reactive B Cell Repertoires
The escape of anti-self B cells from tolerance mechanisms like clonal deletion, receptor editing, and anergy results in the production of autoantibodies, which is a hallmark of many autoimmune disorders. In this study, we demonstrate that both germline sequences and somatic mutations contribute to a...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786517/ https://www.ncbi.nlm.nih.gov/pubmed/29403498 http://dx.doi.org/10.3389/fimmu.2018.00016 |