Simple In Vitro Assay To Evaluate the Incorporation Efficiency of Ribonucleotide Analog 5′-Triphosphates into RNA by Human Mitochondrial DNA-Dependent RNA Polymerase

There is a growing body of evidence suggesting that some ribonucleoside/ribonucleotide analogs may be incorporated into mitochondrial RNA by human mitochondrial DNA-dependent RNA polymerase (POLRMT) and disrupt mitochondrial RNA synthesis. An assessment of the incorporation efficiency of a ribonucle...

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Detalles Bibliográficos
Autores principales: Lu, Gaofei, Bluemling, Gregory R., Mao, Shuli, Hager, Michael, Gurale, Bharat P., Collop, Paul, Kuiper, Damien, Sana, Kasinath, Painter, George R., De La Rosa, Abel, Kolykhalov, Alexander A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Antiviral Agents
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786792/
https://www.ncbi.nlm.nih.gov/pubmed/29180528
http://dx.doi.org/10.1128/AAC.01830-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786792/
https://www.ncbi.nlm.nih.gov/pubmed/29180528
http://dx.doi.org/10.1128/AAC.01830-17

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