KKL-35 Exhibits Potent Antibiotic Activity against Legionella Species Independently of trans-Translation Inhibition

trans-Translation is a ribosome-rescue system that is ubiquitous in bacteria. Small molecules defining a new family of oxadiazole compounds that inhibit trans-translation have been found to have broad-spectrum antibiotic activity. We sought to determine the activity of KKL-35, a potent member of the...

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Detalles Bibliográficos
Autores principales: Brunel, Romain, Descours, Ghislaine, Durieux, Isabelle, Doublet, Patricia, Jarraud, Sophie, Charpentier, Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Mechanisms of Action: Physiological Effects
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786812/
https://www.ncbi.nlm.nih.gov/pubmed/29158279
http://dx.doi.org/10.1128/AAC.01459-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786812/
https://www.ncbi.nlm.nih.gov/pubmed/29158279
http://dx.doi.org/10.1128/AAC.01459-17

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