Prepubertal Ovariectomy Exaggerates Adult Affective Behaviors and Alters the Hippocampal Transcriptome in a Genetic Rat Model of Depression

Major depressive disorder (MDD) is a debilitating illness that affects twice as many women than men postpuberty. This female bias is thought to be caused by greater heritability of MDD in women and increased vulnerability induced by female sex hormones. We tested this hypothesis by removing the ovar...

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Detalles Bibliográficos
Autores principales: Raghavan, Neha S., Chen, Hao, Schipma, Matthew, Luo, Wendy, Chung, Sarah, Wang, Lei, Redei, Eva E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786888/
https://www.ncbi.nlm.nih.gov/pubmed/29403433
http://dx.doi.org/10.3389/fendo.2017.00373

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786888/
https://www.ncbi.nlm.nih.gov/pubmed/29403433
http://dx.doi.org/10.3389/fendo.2017.00373

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