Sequential decitabine and carboplatin treatment increases the DNA repair protein XPC, increases apoptosis and decreases proliferation in melanoma

BACKGROUND: Melanoma has two key features, an over-representation of UV-induced mutations and resistance to DNA damaging chemotherapy agents. Both of these features may result from dysfunction of the nucleotide excision repair pathway, in particular the DNA damage detection branch, global genome rep...

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Detalles Bibliográficos
Autores principales: Budden, Timothy, van der Westhuizen, Andre, Bowden, Nikola A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787239/
https://www.ncbi.nlm.nih.gov/pubmed/29373959
http://dx.doi.org/10.1186/s12885-018-4010-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787239/
https://www.ncbi.nlm.nih.gov/pubmed/29373959
http://dx.doi.org/10.1186/s12885-018-4010-9

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