PD-L1 (CD274) and PD-L2 (PDCD1LG2) promoter methylation is associated with HPV infection and transcriptional repression in head and neck squamous cell carcinomas

BACKGROUND: DNA methylation of the immune checkpoint gene PD-L1 has recently been shown to be associated with PD-L1 mRNA expression in various malignancies. This study aimed to investigate the association of PD-L1 and PD-L2 methylation with mRNA expression, immune cell infitration, protein expressio...

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Detalles Bibliográficos
Autores principales: Franzen, Alina, Vogt, Timo J., Müller, Tim, Dietrich, Jörn, Schröck, Andreas, Golletz, Carsten, Brossart, Peter, Bootz, Friedrich, Landsberg, Jennifer, Kristiansen, Glen, Dietrich, Dimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787495/
https://www.ncbi.nlm.nih.gov/pubmed/29416641
http://dx.doi.org/10.18632/oncotarget.23080

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787495/
https://www.ncbi.nlm.nih.gov/pubmed/29416641
http://dx.doi.org/10.18632/oncotarget.23080

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