Modeling signaling‐dependent pluripotency with Boolean logic to predict cell fate transitions

Pluripotent stem cells (PSCs) exist in multiple stable states, each with specific cellular properties and molecular signatures. The mechanisms that maintain pluripotency, or that cause its destabilization to initiate development, are complex and incompletely understood. We have developed a model to...

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Detalles Bibliográficos
Autores principales: Yachie‐Kinoshita, Ayako, Onishi, Kento, Ostblom, Joel, Langley, Matthew A, Posfai, Eszter, Rossant, Janet, Zandstra, Peter W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787708/
https://www.ncbi.nlm.nih.gov/pubmed/29378814
http://dx.doi.org/10.15252/msb.20177952

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787708/
https://www.ncbi.nlm.nih.gov/pubmed/29378814
http://dx.doi.org/10.15252/msb.20177952

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