Cargando…

Melatonin Mitigates Kainic Acid-Induced Neuronal Tau Hyperphosphorylation and Memory Deficits through Alleviating ER Stress

Kainic acid (KA) exposure causes neuronal degeneration featured by Alzheimer-like tau hyperphosphorylation and memory deficits. Melatonin (Mel) is known to protect hippocampal neurons against KA-induced damage. However, the underlying mechanisms remain elusive. In the current study, we investigated...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shi, Cai, Zeng, Jia, Li, Zixi, Chen, Qingjie, Hang, Weijian, Xia, Liangtao, Wu, Yue, Chen, Juan, Shi, Anbing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787934/ https://www.ncbi.nlm.nih.gov/pubmed/29416502 http://dx.doi.org/10.3389/fnmol.2018.00005

Ejemplares similares

Melatonin Mediates Protective Effects against Kainic Acid-Induced Neuronal Death through Safeguarding ER Stress and Mitochondrial Disturbance
por: Xue, Feixiao, et al.
Publicado: (2017)

Kainic acid hyperphosphorylates tau via inflammasome activation in MAPT transgenic mice
por: Zheng, Xiang-Yu, et al.
Publicado: (2019)

FLZ Alleviates the Memory Deficits in Transgenic Mouse Model of Alzheimer’s Disease via Decreasing Beta-Amyloid Production and Tau Hyperphosphorylation
por: Bao, Xiu-Qi, et al.
Publicado: (2013)

Betaine Alleviates Hypertriglycemia and Tau Hyperphosphorylation in db/db Mice
por: Jung, Ga-young, et al.
Publicado: (2013)

Surfen and oxalyl surfen decrease tau hyperphosphorylation and mitigate neuron deficits in vivo in a zebrafish model of tauopathy
por: Alavi Naini, Seyedeh Maryam, et al.
Publicado: (2018)

Correction to: Surfen and oxalyl surfen decrease tau hyperphosphorylation and mitigate neuron deficits in vivo in a zebrafish model of tauopathy
por: Naini, Seyedeh Maryam Alavi, et al.
Publicado: (2020)

Immunological memory to hyperphosphorylated tau in asymptomatic individuals
por: Pascual, Gabriel, et al.
Publicado: (2017)

Hyperphosphorylation-Induced Tau Oligomers
por: Iqbal, Khalid, et al.
Publicado: (2013)

Berberine Reduces Aβ(42) Deposition and Tau Hyperphosphorylation via Ameliorating Endoplasmic Reticulum Stress
por: Wu, Yue, et al.
Publicado: (2021)

Caspase-6-cleaved Tau fails to induce Tau hyperphosphorylation and aggregation, neurodegeneration, glial inflammation, and cognitive deficits
por: Noël, Anastasia, et al.
Publicado: (2021)

Mitochondrial Oxidative Stress Causes Hyperphosphorylation of Tau
por: Melov, Simon, et al.
Publicado: (2007)

Hyperphosphorylated tau in young and middle-aged subjects
por: Elobeid, Adila, et al.
Publicado: (2011)

PINCH in the Cellular Stress Response to Tau-Hyperphosphorylation
por: Ozdemir, Ahmet Yunus, et al.
Publicado: (2013)

Oligomer Formation of Tau Protein Hyperphosphorylated in Cells
por: Tepper, Katharina, et al.
Publicado: (2014)

Site-Specific Cerebrospinal Fluid Tau Hyperphosphorylation in Response to Alzheimer’s Disease Brain Pathology: Not All Tau Phospho-Sites are Hyperphosphorylated
por: Barthélemy, Nicolas R., et al.
Publicado: (2022)

Chronic cerebral hypoperfusion causes decrease of O-GlcNAcylation, hyperphosphorylation of tau and behavioral deficits in mice
por: Zhao, Yang, et al.
Publicado: (2014)

Zinc Binding Directly Regulates Tau Toxicity Independent of Tau Hyperphosphorylation
por: Huang, Yunpeng, et al.
Publicado: (2014)

Hyperphosphorylation and Cleavage at D421 Enhance Tau Secretion
por: Plouffe, Vanessa, et al.
Publicado: (2012)

Evidence of Tau Hyperphosphorylation and Dystrophic Microglia in the Common Marmoset
por: Rodriguez-Callejas, Juan D., et al.
Publicado: (2016)

Intranasal NAP (davunetide) decreases tau hyperphosphorylation and moderately improves behavioral deficits in mice overexpressing α-synuclein
por: Magen, Iddo, et al.
Publicado: (2014)

Sex hormone-related neurosteroids differentially rescue bioenergetic deficits induced by amyloid-β or hyperphosphorylated tau protein
por: Grimm, Amandine, et al.
Publicado: (2015)

Identification of the Sites of Tau Hyperphosphorylation and Activation of Tau Kinases in Synucleinopathies and Alzheimer’s Diseases
por: Duka, Valeriy, et al.
Publicado: (2013)

The Role of α-synuclein and Tau Hyperphosphorylation-Mediated Autophagy and Apoptosis in Lead-induced Learning and Memory Injury
por: Zhang, Jianbin, et al.
Publicado: (2012)

Calcium Ions Stimulate the Hyperphosphorylation of Tau by Activating Microsomal Prostaglandin E Synthase 1
por: Cao, Long-Long, et al.
Publicado: (2019)

Conditional inactivation of Akt three isoforms causes tau hyperphosphorylation in the brain
por: Wang, Long, et al.
Publicado: (2015)

Dimethyl Sulfoxide Induces Both Direct and Indirect Tau Hyperphosphorylation
por: Julien, Carl, et al.
Publicado: (2012)

Suppression of LPS-induced tau hyperphosphorylation by serum amyloid A
por: Liu, Jin, et al.
Publicado: (2016)

Iron Deposition Leads to Hyperphosphorylation of Tau and Disruption of Insulin Signaling
por: Wan, Wenbin, et al.
Publicado: (2019)

Corrigendum: Evidence of Tau Hyperphosphorylation and Dystrophic Microglia in the Common Marmoset
por: Rodriguez-Callejas, Juan D., et al.
Publicado: (2017)

Cellular polyamines condense hyperphosphorylated Tau, triggering Alzheimer’s disease
por: Ivanov, Stefan M., et al.
Publicado: (2020)

Pathological Tau From Alzheimer’s Brain Induces Site-Specific Hyperphosphorylation and SDS- and Reducing Agent-Resistant Aggregation of Tau in vivo
por: Miao, Jin, et al.
Publicado: (2019)

Differential Hyperphosphorylation of Tau-S199, -T231 and -S396 in Organotypic Brain Slices of Alzheimer Mice. A Model to Study Early Tau Hyperphosphorylation Using Okadaic Acid
por: Foidl, Bettina M., et al.
Publicado: (2018)

Indirubin-3′-monoxime suppresses amyloid-beta-induced apoptosis by inhibiting tau hyperphosphorylation
por: Zhang, Shu-gang, et al.
Publicado: (2016)

The Ambiguous Relationship of Oxidative Stress, Tau Hyperphosphorylation, and Autophagy Dysfunction in Alzheimer's Disease
por: Liu, Zhenzhen, et al.
Publicado: (2015)

Genome-Wide Epistasis Study of Cerebrospinal Fluid Hyperphosphorylated Tau in ADNI Cohort
por: Chen, Dandan, et al.
Publicado: (2023)

Alzheimer-related decrease in CYFIP2 links amyloid production to tau hyperphosphorylation and memory loss
por: Tiwari, Sachin Suresh, et al.
Publicado: (2016)

Cornel iridoid glycoside ameliorates cognitive deficits in APP/PS1/tau triple transgenic mice by attenuating amyloid-beta, tau hyperphosphorylation and neurotrophic dysfunction
por: Yang, Cuicui, et al.
Publicado: (2020)

Codonopsis pilosula Polysaccharide Attenuates Tau Hyperphosphorylation and Cognitive Impairments in hTau Infected Mice
por: Zhang, Qing, et al.
Publicado: (2018)

Expression of Concern: Identification of the Sites of Tau Hyperphosphorylation and Activation of Tau Kinases in Synucleinopathies and Alzheimer’s Diseases
Publicado: (2023)

Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction
por: Zhang, Xingyu, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_3c9p0u9taglcidp10jvt9bidak