PD-L1 checkpoint inhibition and anti-CTLA-4 whole tumor cell vaccination counter adaptive immune resistance: A mouse neuroblastoma model that mimics human disease

BACKGROUND: Adaptive immune resistance induces an immunosuppressive tumor environment that enables immune evasion. This phenomenon results in tumor escape with progression and metastasis. Programmed cell death-ligand 1 (PD-L1) expressed on tumors is thought to inhibit tumor-infiltrating lymphocytes...

Descripción completa

Detalles Bibliográficos
Autores principales: Srinivasan, Priya, Wu, Xiaofang, Basu, Mousumi, Rossi, Christopher, Sandler, Anthony D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788338/
https://www.ncbi.nlm.nih.gov/pubmed/29377881
http://dx.doi.org/10.1371/journal.pmed.1002497

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788338/
https://www.ncbi.nlm.nih.gov/pubmed/29377881
http://dx.doi.org/10.1371/journal.pmed.1002497

Ejemplares similares