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Enhanced susceptibility to stress and seizures in GAD65 deficient mice
Reduced gamma-aminobutyric acid (GABA) inhibition has been implicated in both anxiety and epilepsy. GAD65(-/-) (NOD/LtJ) mice have significantly decreased basal GABA levels in the brain and a lowered threshold for seizure generation. One fifth of GAD65 (-/-) mice experienced stress-induced seizures...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788371/ https://www.ncbi.nlm.nih.gov/pubmed/29377906 http://dx.doi.org/10.1371/journal.pone.0191794 |