Mask mitigates MAPT- and FUS-induced degeneration by enhancing autophagy through lysosomal acidification

Accumulation of intracellular misfolded or damaged proteins is associated with both normal aging and late-onset degenerative diseases. Two cellular clearance mechanisms, the ubiquitin-proteasome system (UPS) and the macroautophagy/autophagy-lysosomal pathway, work in concert to degrade harmful prote...

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Detalles Bibliográficos
Autores principales: Zhu, Mingwei, Zhang, Sheng, Tian, Xiaolin, Wu, Chunlai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Basic Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788473/
https://www.ncbi.nlm.nih.gov/pubmed/28806139
http://dx.doi.org/10.1080/15548627.2017.1362524

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788473/
https://www.ncbi.nlm.nih.gov/pubmed/28806139
http://dx.doi.org/10.1080/15548627.2017.1362524

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