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Mask mitigates MAPT- and FUS-induced degeneration by enhancing autophagy through lysosomal acidification
Accumulation of intracellular misfolded or damaged proteins is associated with both normal aging and late-onset degenerative diseases. Two cellular clearance mechanisms, the ubiquitin-proteasome system (UPS) and the macroautophagy/autophagy-lysosomal pathway, work in concert to degrade harmful prote...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788473/ https://www.ncbi.nlm.nih.gov/pubmed/28806139 http://dx.doi.org/10.1080/15548627.2017.1362524 |