Hepatitis B virus core protein allosteric modulators can distort and disrupt intact capsids

Defining mechanisms of direct-acting antivirals facilitates drug development and our understanding of virus function. Heteroaryldihydropyrimidines (HAPs) inappropriately activate assembly of hepatitis B virus (HBV) core protein (Cp), suppressing formation of virions. We examined a fluorophore-labele...

Descripción completa

Detalles Bibliográficos
Autores principales: Schlicksup, Christopher John, Wang, Joseph Che-Yen, Francis, Samson, Venkatakrishnan, Balasubramanian, Turner, William W, VanNieuwenhze, Michael, Zlotnick, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788503/
https://www.ncbi.nlm.nih.gov/pubmed/29377794
http://dx.doi.org/10.7554/eLife.31473

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788503/
https://www.ncbi.nlm.nih.gov/pubmed/29377794
http://dx.doi.org/10.7554/eLife.31473

Ejemplares similares