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Hepatitis B virus core protein allosteric modulators can distort and disrupt intact capsids

Defining mechanisms of direct-acting antivirals facilitates drug development and our understanding of virus function. Heteroaryldihydropyrimidines (HAPs) inappropriately activate assembly of hepatitis B virus (HBV) core protein (Cp), suppressing formation of virions. We examined a fluorophore-labele...

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Detalles Bibliográficos
Autores principales:	Schlicksup, Christopher John, Wang, Joseph Che-Yen, Francis, Samson, Venkatakrishnan, Balasubramanian, Turner, William W, VanNieuwenhze, Michael, Zlotnick, Adam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788503/ https://www.ncbi.nlm.nih.gov/pubmed/29377794 http://dx.doi.org/10.7554/eLife.31473

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