HPRT1 activity loss is associated with resistance to thiopurine in ALL

Acute lymphoblastic leukemia (ALL) is an aggressive hematological tumor resulting from the malignant transformation of lymphoid progenitors. Thiopurine is a widely used drug in the maintaining treatment of ALL. After a period of chemotherapy, 20% of pediatric patients and over 50% of adult patients...

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Detalles Bibliográficos
Autores principales: Yang, Fan, Fang, Houshun, Wang, Dan, Chen, Yao, Zhai, Yonggong, Zhou, Bin-Bing S., Li, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788638/
https://www.ncbi.nlm.nih.gov/pubmed/29416770
http://dx.doi.org/10.18632/oncotarget.23405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788638/
https://www.ncbi.nlm.nih.gov/pubmed/29416770
http://dx.doi.org/10.18632/oncotarget.23405

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