The alpha7-nicotinic receptor contributes to gp120-induced neurotoxicity: implications in HIV-associated neurocognitive disorders

Currently, there are no specific therapies to treat HIV-1 associated neurocognitive disorders (HAND). The HIV-1 envelope, gp120, induces neuropathological changes similar to those in HAND patients; furthermore, it triggers an upregulation of the α7-nicotinic acetylcholine receptor (α7-nAChR), facili...

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Detalles Bibliográficos
Autores principales: Capó-Vélez, Coral M., Morales-Vargas, Bryan, García-González, Aurian, Grajales-Reyes, José G., Delgado-Vélez, Manuel, Madera, Bismark, Báez-Pagán, Carlos A., Quesada, Orestes, Lasalde-Dominicci, José A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788855/
https://www.ncbi.nlm.nih.gov/pubmed/29379089
http://dx.doi.org/10.1038/s41598-018-20271-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788855/
https://www.ncbi.nlm.nih.gov/pubmed/29379089
http://dx.doi.org/10.1038/s41598-018-20271-x

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