Atypical changes in DRG neuron excitability and complex pain phenotype associated with a Na(v)1.7 mutation that massively hyperpolarizes activation

Sodium channel Na(v)1.7 plays a central role in pain-signaling: gain-of-function Na(v)1.7 mutations usually cause severe pain and loss-of-function mutations produce insensitivity to pain. The Na(v)1.7 I234T gain-of-function mutation, however, is linked to a dual clinical presentation of episodic pai...

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Detalles Bibliográficos
Autores principales: Huang, Jianying, Mis, Malgorzata A., Tanaka, Brian, Adi, Talia, Estacion, Mark, Liu, Shujun, Walker, Suellen, Dib-Hajj, Sulayman D., Waxman, Stephen G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788866/
https://www.ncbi.nlm.nih.gov/pubmed/29379075
http://dx.doi.org/10.1038/s41598-018-20221-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788866/
https://www.ncbi.nlm.nih.gov/pubmed/29379075
http://dx.doi.org/10.1038/s41598-018-20221-7

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