The SAM domain of mouse SAMHD1 is critical for its activation and regulation

Human SAMHD1 (hSAMHD1) is a retroviral restriction factor that blocks HIV-1 infection by depleting the cellular nucleotides required for viral reverse transcription. SAMHD1 is allosterically activated by nucleotides that induce assembly of the active tetramer. Although the catalytic core of hSAMHD1...

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Detalles Bibliográficos
Autores principales: Buzovetsky, Olga, Tang, Chenxiang, Knecht, Kirsten M., Antonucci, Jenna M., Wu, Li, Ji, Xiaoyun, Xiong, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788916/
https://www.ncbi.nlm.nih.gov/pubmed/29379009
http://dx.doi.org/10.1038/s41467-017-02783-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788916/
https://www.ncbi.nlm.nih.gov/pubmed/29379009
http://dx.doi.org/10.1038/s41467-017-02783-8

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