Global ubiquitination analysis reveals extensive modification and proteasomal degradation of cowpox virus proteins, but preservation of viral cores

The emergence of Variola virus-like viruses by natural evolution of zoonotic Orthopoxviruses, like Cowpox virus (CPXV), is a global health threat. The proteasome is essential for poxvirus replication, making the viral components interacting with the ubiquitin-proteasome system attractive antiviral t...

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Detalles Bibliográficos
Autores principales: Grossegesse, Marica, Doellinger, Joerg, Fritsch, Annemarie, Laue, Michael, Piesker, Janett, Schaade, Lars, Nitsche, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788924/
https://www.ncbi.nlm.nih.gov/pubmed/29379051
http://dx.doi.org/10.1038/s41598-018-20130-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788924/
https://www.ncbi.nlm.nih.gov/pubmed/29379051
http://dx.doi.org/10.1038/s41598-018-20130-9

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