Downregulation of glutamic acid decarboxylase in Drosophila TDP-43-null brains provokes paralysis by affecting the organization of the neuromuscular synapses

Amyotrophic lateral sclerosis is a progressive neurodegenerative disease that affects the motor system, comprised of motoneurons and associated glia. Accordingly, neuronal or glial defects in TDP-43 function provoke paralysis due to the degeneration of the neuromuscular synapses in Drosophila. To id...

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Detalles Bibliográficos
Autores principales: Romano, Giulia, Holodkov, Nikola, Klima, Raffaella, Grilli, Federica, Guarnaccia, Corrado, Nizzardo, Monica, Rizzo, Federica, Garcia, Rodolfo, Feiguin, Fabian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789004/
https://www.ncbi.nlm.nih.gov/pubmed/29379112
http://dx.doi.org/10.1038/s41598-018-19802-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789004/
https://www.ncbi.nlm.nih.gov/pubmed/29379112
http://dx.doi.org/10.1038/s41598-018-19802-3

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