Diversity Modification and Structure-Activity Relationships of Two Natural Products 1β-hydroxy Alantolactone and Ivangustin as Potent Cytotoxic Agents

Sesquiterpene lactones (STLs) are a class of plant secondary metabolites widely found in nature with potent antitumor activities. In this work, two isolated STLs 1β-hydroxy alantolactone (1) and ivangustin (2) were derivatized through diversity-oriented strategy, and in vitro cytotoxic activity asse...

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Detalles Bibliográficos
Autores principales: Tang, Jiang-Jiang, He, Qiu-Rui, Dong, Shuai, Guo, Xin, Wang, Yu-Gong, Lei, Bei-Lei, Tian, Jun-Mian, Gao, Jin-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789092/
https://www.ncbi.nlm.nih.gov/pubmed/29379131
http://dx.doi.org/10.1038/s41598-018-20192-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789092/
https://www.ncbi.nlm.nih.gov/pubmed/29379131
http://dx.doi.org/10.1038/s41598-018-20192-9

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