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Diversity Modification and Structure-Activity Relationships of Two Natural Products 1β-hydroxy Alantolactone and Ivangustin as Potent Cytotoxic Agents

Sesquiterpene lactones (STLs) are a class of plant secondary metabolites widely found in nature with potent antitumor activities. In this work, two isolated STLs 1β-hydroxy alantolactone (1) and ivangustin (2) were derivatized through diversity-oriented strategy, and in vitro cytotoxic activity asse...

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Detalles Bibliográficos
Autores principales:	Tang, Jiang-Jiang, He, Qiu-Rui, Dong, Shuai, Guo, Xin, Wang, Yu-Gong, Lei, Bei-Lei, Tian, Jun-Mian, Gao, Jin-Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789092/ https://www.ncbi.nlm.nih.gov/pubmed/29379131 http://dx.doi.org/10.1038/s41598-018-20192-9

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