Translocation Breakpoints Preferentially Occur in Euchromatin and Acrocentric Chromosomes

Chromosomal translocations drive the development of many hematological and some solid cancers. Several factors have been identified to explain the non-random occurrence of translocation breakpoints in the genome. These include chromatin density, gene density and CCCTC-binding factor (CTCF)/cohesin b...

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Detalles Bibliográficos
Autores principales: Lin, Cheng-Yu, Shukla, Ankit, Grady, John P., Fink, J. Lynn, Dray, Eloise, Duijf, Pascal H.G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789363/
https://www.ncbi.nlm.nih.gov/pubmed/29316705
http://dx.doi.org/10.3390/cancers10010013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789363/
https://www.ncbi.nlm.nih.gov/pubmed/29316705
http://dx.doi.org/10.3390/cancers10010013

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