Cargando…
Continuous activity of Foxo1 is required to prevent anergy and maintain the memory state of CD8(+) T cells
Upon infection with an intracellular pathogen, cytotoxic CD8(+) T cells develop diverse differentiation states characterized by function, localization, longevity, and the capacity for self-renewal. The program of differentiation is determined, in part, by FOXO1, a transcription factor known to integ...
Autores principales: | Delpoux, Arnaud, Michelini, Rodrigo Hess, Verma, Shilpi, Lai, Chen-Yen, Omilusik, Kyla D., Utzschneider, Daniel T., Redwood, Alec J., Goldrath, Ananda W., Benedict, Chris A., Hedrick, Stephen M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789410/ https://www.ncbi.nlm.nih.gov/pubmed/29282254 http://dx.doi.org/10.1084/jem.20170697 |
Ejemplares similares
-
Differentiation of CD8 memory T cells depends on Foxo1
por: Michelini, Rodrigo Hess, et al.
Publicado: (2013) -
Systems-level identification of key transcription factors in immune cell specification
por: Liu, Cong, et al.
Publicado: (2022) -
Sustained Id2 regulation of E proteins is required for terminal differentiation of effector CD8(+) T cells
por: Omilusik, Kyla D., et al.
Publicado: (2018) -
Id3 expression identifies CD4(+) memory Th1 cells
por: Shaw, Laura A., et al.
Publicado: (2022) -
Bromodomain protein BRD4 directs and sustains CD8 T cell differentiation during infection
por: Milner, J. Justin, et al.
Publicado: (2021)