Chromosome conformation signatures define predictive markers of inadequate response to methotrexate in early rheumatoid arthritis

BACKGROUND: There is a pressing need in rheumatoid arthritis (RA) to identify patients who will not respond to first-line disease-modifying anti-rheumatic drugs (DMARD). We explored whether differences in genomic architecture represented by a chromosome conformation signature (CCS) in blood taken fr...

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Detalles Bibliográficos
Autores principales: Carini, Claudio, Hunter, Ewan, Ramadass, Aroul S., Green, Jayne, Akoulitchev, Alexandre, McInnes, Iain B., Goodyear, Carl S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789697/
https://www.ncbi.nlm.nih.gov/pubmed/29378619
http://dx.doi.org/10.1186/s12967-018-1387-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789697/
https://www.ncbi.nlm.nih.gov/pubmed/29378619
http://dx.doi.org/10.1186/s12967-018-1387-9

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