Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer

In mammals, the canonical somatic DNA methylation landscape is established upon specification of the embryo proper and subsequently disrupted within many cancer types(1-4). However, the underlying mechanisms that direct this genome-scale transformation remain elusive, with no clear model for its sys...

Descripción completa

Detalles Bibliográficos
Autores principales: Smith, Zachary D., Shi, Jiantao, Gu, Hongcang, Donaghey, Julie, Clement, Kendell, Cacciarelli, Davide, Gnirke, Andreas, Michor, Franziska, Meissner, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789792/
https://www.ncbi.nlm.nih.gov/pubmed/28959968
http://dx.doi.org/10.1038/nature23891

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789792/
https://www.ncbi.nlm.nih.gov/pubmed/28959968
http://dx.doi.org/10.1038/nature23891

Ejemplares similares