Structure-guided design of an Hsp90β N-terminal isoform-selective inhibitor

The 90 kDa heat shock protein (Hsp90) is a molecular chaperone responsible for folding proteins that are directly associated with cancer progression. Consequently, inhibition of the Hsp90 protein folding machinery results in a combinatorial attack on numerous oncogenic pathways. Seventeen small-mole...

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Detalles Bibliográficos
Autores principales: Khandelwal, Anuj, Kent, Caitlin N., Balch, Maurie, Peng, Shuxia, Mishra, Sanket J., Deng, Junpeng, Day, Victor W., Liu, Weiya, Subramanian, Chitra, Cohen, Mark, Holzbeierlein, Jeffery M., Matts, Robert, Blagg, Brian S. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789826/
https://www.ncbi.nlm.nih.gov/pubmed/29382832
http://dx.doi.org/10.1038/s41467-017-02013-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789826/
https://www.ncbi.nlm.nih.gov/pubmed/29382832
http://dx.doi.org/10.1038/s41467-017-02013-1

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