Gimap5-dependent inactivation of GSK3β is required for CD4(+) T cell homeostasis and prevention of immune pathology

GTPase of immunity-associated protein 5 (Gimap5) is linked with lymphocyte survival, autoimmunity, and colitis, but its mechanisms of action are unclear. Here, we show that Gimap5 is essential for the inactivation of glycogen synthase kinase-3β (GSK3β) following T cell activation. In the absence of...

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Detalles Bibliográficos
Autores principales: Patterson, Andrew R., Endale, Mehari, Lampe, Kristin, Aksoylar, Halil I., Flagg, Aron, Woodgett, Jim R., Hildeman, David, Jordan, Michael B., Singh, Harinder, Kucuk, Zeynep, Bleesing, Jack, Hoebe, Kasper
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789891/
https://www.ncbi.nlm.nih.gov/pubmed/29382851
http://dx.doi.org/10.1038/s41467-018-02897-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789891/
https://www.ncbi.nlm.nih.gov/pubmed/29382851
http://dx.doi.org/10.1038/s41467-018-02897-7

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