Structural heterogeneity and intersubject variability of Aβ in familial and sporadic Alzheimer’s disease

Point mutations in the amyloid-β (Aβ) coding region produce a combination of mutant and WT Aβ isoforms that yield unique clinicopathologies in familial Alzheimer’s disease (fAD) and cerebral amyloid angiopathy (fCAA) patients. Here, we report a method to investigate the structural variability of amy...

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Detalles Bibliográficos
Autores principales: Condello, Carlo, Lemmin, Thomas, Stöhr, Jan, Nick, Mimi, Wu, Yibing, Maxwell, Alison M., Watts, Joel C., Caro, Christoffer D., Oehler, Abby, Keene, C. Dirk, Bird, Thomas D., van Duinen, Sjoerd G., Lannfelt, Lars, Ingelsson, Martin, Graff, Caroline, Giles, Kurt, DeGrado, William F., Prusiner, Stanley B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789926/
https://www.ncbi.nlm.nih.gov/pubmed/29311311
http://dx.doi.org/10.1073/pnas.1714966115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789926/
https://www.ncbi.nlm.nih.gov/pubmed/29311311
http://dx.doi.org/10.1073/pnas.1714966115

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