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Fitness landscape of the human immunodeficiency virus envelope protein that is targeted by antibodies

HIV is a highly mutable virus, and over 30 years after its discovery, a vaccine or cure is still not available. The isolation of broadly neutralizing antibodies (bnAbs) from HIV-infected patients has led to renewed hope for a prophylactic vaccine capable of combating the scourge of HIV. A major chal...

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Detalles Bibliográficos
Autores principales: Louie, Raymond H. Y., Kaczorowski, Kevin J., Barton, John P., Chakraborty, Arup K., McKay, Matthew R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789945/
https://www.ncbi.nlm.nih.gov/pubmed/29311326
http://dx.doi.org/10.1073/pnas.1717765115