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Structure of the C1r–C1s interaction of the C1 complex of complement activation
The multiprotein complex C1 initiates the classical pathway of complement activation on binding to antibody–antigen complexes, pathogen surfaces, apoptotic cells, and polyanionic structures. It is formed from the recognition subcomponent C1q and a tetramer of proteases C1r(2)C1s(2) as a Ca(2+)-depen...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789954/ https://www.ncbi.nlm.nih.gov/pubmed/29311313 http://dx.doi.org/10.1073/pnas.1718709115 |