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Rational CCL5 mutagenesis integration in a lactobacilli platform generates extremely potent HIV-1 blockers
Efforts to improve existing anti-HIV-1 therapies or develop preventatives have identified CCR5 as an important target and CCL5 as an ideal scaffold to sculpt potent HIV-1 entry inhibitors. We created novel human CCL5 variants that exhibit exceptional anti-HIV-1 features using recombinant lactobacill...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790001/ https://www.ncbi.nlm.nih.gov/pubmed/29382912 http://dx.doi.org/10.1038/s41598-018-20300-9 |