The Effects of 2′-O-Methoxyethyl Oligonucleotides on Renal Function in Humans

Systemically administered 2′-O-methoxyethyl (2′MOE) antisense oligonucleotides (ASOs) accumulate in the kidney and metabolites are cleared in urine. The effects of eleven 2′MOE ASOs on renal function were assessed in 2,435 patients from 32 phase 2 and phase 3 trials. The principle analysis was on da...

Descripción completa

Detalles Bibliográficos
Autores principales: Crooke, Stanley T., Baker, Brenda F., Pham, Nguyen C., Hughes, Steven G., Kwoh, T. Jesse, Cai, Danlin, Tsimikas, Sotirios, Geary, Richard S., Bhanot, Sanjay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790433/
https://www.ncbi.nlm.nih.gov/pubmed/29185862
http://dx.doi.org/10.1089/nat.2017.0693

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790433/
https://www.ncbi.nlm.nih.gov/pubmed/29185862
http://dx.doi.org/10.1089/nat.2017.0693

Ejemplares similares