Brain- and brain tumor-penetrating disulfiram nanoparticles: Sequence of cytotoxic events and efficacy in human glioma cell lines and intracranial xenografts

There is great interest in repurposing disulfiram (DSF), a rapidly metabolizing nontoxic drug, for brain cancers and other cancers. To overcome the instability and low therapeutic efficacy, we engineered passively-targeted DSF-nanoparticles (DSFNPs) using biodegradable monomethoxy (polyethylene glyc...

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Detalles Bibliográficos
Autores principales: Madala, Hanumantha Rao, Punganuru, Surendra R., Ali-Osman, Francis, Zhang, Ruiwen, Srivenugopal, Kalkunte S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790476/
https://www.ncbi.nlm.nih.gov/pubmed/29423059
http://dx.doi.org/10.18632/oncotarget.23320

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790476/
https://www.ncbi.nlm.nih.gov/pubmed/29423059
http://dx.doi.org/10.18632/oncotarget.23320

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