Combined effects of PLK1 and RAS in hepatocellular carcinoma reveal rigosertib as promising novel therapeutic “dual-hit” option

Inhibition of RAS-RAF-ERK-signaling is a major mechanism mediated by the multi-kinase inhibitors sorafenib and regorafenib, the only effective therapeutic approaches for advanced hepatocellular carcinoma (HCC). This underlines the importance of RAS-RAF-ERK-signaling in HCC. Most RAS isoforms were no...

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Detalles Bibliográficos
Autores principales: Dietrich, Peter, Freese, Kim, Mahli, Abdo, Thasler, Wolfgang Erwin, Hellerbrand, Claus, Bosserhoff, Anja Katrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790486/
https://www.ncbi.nlm.nih.gov/pubmed/29423069
http://dx.doi.org/10.18632/oncotarget.23188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790486/
https://www.ncbi.nlm.nih.gov/pubmed/29423069
http://dx.doi.org/10.18632/oncotarget.23188

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